A late goal cruelly went against the Blades in Sunday's Yorkshire derby at Bramall Lane.
In an entertaining clash, which both teams could have won, Patrick Bamford's late header proved decisive for the visitors.
For the clash against Marcelo Bielsa's side, Wilder was forced into changes. Egan (suspension) and O'Connell (knee) missed out, whilst Fleck was only fit enough to be named amongst the substitutes. Ampadu was handed his full United league debut, with Robinson also named in the starting XI.
Inside the opening four minutes United had a couple of early scares. Firstly, Harrison was freed down the left, but Basham was ideally positioned to clear the danger, then Ayling found some space and drew a diving save from Ramsdale. At the other end, McGoldrick was cleaned out by Phillips, who was subsequently booked, after Lundstram had dragged an effort wide from Burke's pass.
Midway through the first period, United fashioned a chance for Baldock at the back post after some excellent build-up play that ended with Burke laying off for Osborn to cross, but Harrison read the danger and cleared his lines. In response, from a free kick on the right, Bamford headed over from a Phillips delivery, before Ramsdale comfortably saved a deflected effort from Klich.
On the half hour, the Blades should have taken the lead. Ayling surrendered position on halfway, United broke and from Osborn's low cross only an excellent save from Meslier denied an advancing Lundstram from opening the scoring. The game continued to see both teams create chances, this time it was the visitors through Harrison on the left that found time and space for a cross, but thankfully Bamford's header was too high.
As half-time approached the game followed the same pattern of both teams have chancing, Burke and McGoldrick for the Blades following an Ayling slip, before Ramsdale was forced into action to tip away a Dallas shot and from the resulting corner, Cooper headed wide under pressure. Back on the attack, the Blades cut Leeds open again, with Osborn again instrumental, only for Meslier to tip over Baldock's effort. And from the corner that followed, referee Tierney waved way appeals for a penalty as Ampadu went down with Dallas perhaps guilty of a tug and push.
It was Leeds who had the first shot on goal in the second half, but Ramsdale was equal to Costa's back post volley, after McGoldrick had only partially cleared. The visitors continued to force the issue, but this time Ramsdale denied Bamford at his near post, before showing assured handling to claim the resulting corner.
With the hour mark in sight, Lundstram was booked for a trip on an advancing Dallas which halted a potential counter. United were gradually getting back into the contest and some neat play on the right ended with Stevens stinging the palms of Meslier on the angle. But moments later, the Blades just about survived a real moment of danger. Dallas rounded Ramsdale from a long ball that was allowed to run, but Basham managed to rearrange his body shape and clear in the nick of time.
On 64 minutes, Wilder made his first chance, with Norwood replacing Lundstram, as Berge stepped further forward in midfield. But it was Leeds substitute Rodrigo that should have done better with a near post header from Dallas's cross from the left. Still the game ebbed and flowed, with both sides looking to break the deadlock. Ampadu made a vital block from Rodrigo's effort but it came at a cost as he needed lengthy treatment for a facial injury before getting back to his feet.
Sharp and McBurnie replaced Burke and McGoldrick with 16 minutes left to play. From a United corner, Leeds broke at pace, but Ramsdale denied Poveda, before tipping behind from a deep cross from Klich. But from the next Blades corner, Robinson diverted Osborn's inviting centre inches wide of the far post with Meslier beaten as United themselves came close to the opener.
In what had been an end-to-end game throughout, the contest finished in the same manner. Ramsdale denied Dallas, whilst only a block from Koch denied Sharp at the other end as he looked to latch on to a long clearance. But with two minutes, Leeds dealt the Blades a cruel blow as BAMFORD headed home at the back post from Harrison's cross.
Five minutes of added time were signalled and the Blades, with Basham in attack tried everything to get an equaliser, but from a promising position, Osborn couldn't find a telling ball and that was the last action of note.
Blades: Ramsdale, Baldock, Stevens, Basham, Lundstram (Norwood 64), Berge, Burke (Sharp 74), McGoldrick (McBurnie 74), Robinson, Ampadu, Osborn.
Subs: Fleck, Lowe, Jagielka, Foderingham.
Leeds: Meslier, Ayling, Koch, Cooper, Dallas, Phillips, Klich, Costa (Poveda 67), Roberts (Rodrigo 45, Alioski 90), Harrison, Bamford.
Subs: Caprile, Struijk, Davis, Shackleton.
As it happened...
Oli Burke is over the ball, United to kick-off and the Yorkshire derby is underway!
United make the first forays forward after winning a series of throws deep inside Leeds' half.
David McGoldrick tries to win a corner tight into the corner but the ball deflects back off him for a goal kick.
Leeds break at the other end as Bamford and Klich combine before the ball is played to Harrison. He cuts the ball back into the area no-one there for Leeds and United clear.
Leeds now into their stride. Ayling found in space, he drives forward cuts one way and then another before unleashing a shot which Ramsdale parries clear low to his right.
Chance for United.
Phillips cleans out McGoldrick in the build up, eventually Lundstram is playesd into the left of the area but drags his shot wide.
Phillips was given a yellow after the attack ended for the challenge on McGoldrick.
United win the ball just inside our own half and break through Berge.
He plays the ball to the right to find McGoldrick who fires in a low cross which is deflected and it kindly rolls into the grasp of Meslier.
Ball over the top by Osborn for McGoldrick to chase but Meslier sprints off his line to claim the ball just inside his area in the nick of time.
Dallas down the right shanks a cross behind for a goal kick.
Nothing really has happened over the last five minutes.
Great pressing by Burke as United win the ball back but he's been penalised by the referee. Debatle one but it's a free-kick to Leeds.
Some neat play by Ampadu as he brings down a ball on halfway and advances into the Leeds half, the pass though is loose and goes through to Meslier.
United step it and enjoy some posession.
Osborn with a dangerous cross into the area cleared by Phillips, then Burke with a run across the area, laying a pass to Lundstram whose shot is blocked.
Chance for Leeds.
Foul by Stevens gives Phillips an opportunity to cross and it is a dangerous ball in which is headed over by Bamford.
Deflected effort from Klich loops into the hands of Ramsdale.
Leeds just stepping it up again now...
United win a free-kick after a foul on McGoldrick. Delivered by Lundstram, Robinson gets something on it, but directs a low header wide.
What a chance for United.
Loose pass by Ayling, United break. Osborn with the cross, touch or dummy by McGoldrick and Lundstram is there but his low shot is saved by Meslier. It's a brilliant stop and Leeds clear the corner.
Leeds respond with a lovely cross from Harrison to find Bamford between the defenders but he heads over.
Neat play again by United down the right as Burke finds Basham but the cross is too close to Meslier who picks it up on the bounce.
Contentious from the official as Basham is pushed in the back but he's penalised for landing on the ball with his hands.
The free-kick is poor and it's whipped out of play at the far stick.
Charging run from Burke who sees his first effort from a tight angle blocked. He then forces the ball to McGoldrick on the edge of the area but he fires well over.
Neat play by Leeds in and around the edge of the area ends with Dallas sending a shot towards the top corner but Ramsdale dives to his right to tip it around the post.
The resulting corner is glanced well wide.
Driving run by Osborn, he slides a pass into Baldock who fires a fierce shot towards goal on the angle and Meslier tips it over the bar.
Osborn's centre looks perfect for Ampadu running in on the cross, he appeals for a penalty as he goes down but nothing given.
Terrific pass from Lundstram, and Burke sprints down the left and cuts in onto his right. He gets a shot away but it's blocked by a Leeds defender.
One added minute.
Blades 0 - 0 Leeds
Very watchable game, chances at both ends. United going closest when Lundstram's effort was pushed away following a brilliant save by Meslier.
Patrick Bamford over the ball, Leeds kick-off and we're underway again.
Leeds change at half-time. Tyler Roberts makes way for Rodrigo Moreno.
Leeds win a corner at the start of the second half. Phillips with the corner headed away by McGoldrick, Costa with the shot and a brilliant save low down by Ramsdale.
A deflected pass from Baldock goes behind for a corner. Osborn goes to the near post but McGoldrick's flick is blocked.
Stevens heads a deep cross to the back post behind for a corner.
Phillips swings it in but it has gone out before it comes back and it's a goal kick to United.
Brilliant clearance on the stretch by Robinson after he gives away a free-kick on the far side.
Ramsdale does really well to hold onto a deflected shot with Leeds players lurking.
Good spell for the visitors here.
Osborn loses the ball in a bad area, ends with a Bamford shot and another good save from Ramsdale.
Lovely interplay as Basham plays a one-two at the byline but Leeds clear the low cross into the near post.
Yellow for Lundstram as he halts a Leeds attack.
Nice play from United again.
Lundstram combining with Stevens who hits a low shot from 20 yards, parried by Meslier.
What a chance for Leeds.
Ampadu misses a through ball, Bamford is onto it, beats Ramsdale to the loose ball, but the shot didn't have the legs as Basham runs around the other side to clear.
Here comes a change for United.
Lundstram replaced by Ollie Norwood.
Dallas with a brilliant run and cross into the area, headed wide by Rodrigo.
Sub for Leeds. Helder Costa replaced by Ian Poveda.
Yellow for Baldock after a sliding challenge on Dallas.
Berge with a break from deep, gets lucky riding one challenge but then puts a lovely pass into Osborn who cuts inside to shoot but his effort is blocked.
At the other end, Ampadu is down after taking one in the face.
Patient build up by Leeds ends with a Rodrigo shot comfortably held by Ramsdale.
Double change for United as Billy Sharp replaces Oli Burke.
Oli McBurnie also on for David McGoldrick.
Great play by Berge who takes on Dallas but the low cross is cut out at the near post.
Good hold up play by McBurnie, plays it to Osborn and the low cross is off a Leeds player and behind for a corner.
Leeds clear the centre from the far side.
Leeds break and Ramsdale makes another save.
Then a cross goes in and the 'keeper takes no chances and tips wide.
Nothing comes from Harrison's centre...
Berge wins the ball and sets Baldock going, he cuts inside but the shot is deflected wide.
Osborn's corner somehow goes wide after Robinson gets a touch.
Baldock with nice interplay with McBurnie but the touch is too heavy as he tries to run clear and Meslier gets there ahead of him as both collide.
Dallas with a long range effort which is well held by Ramsdale.
At the other end a snapshot from Sharp is deflected into the hands of Meslier.
Goal for Leeds.
Cross from the right by Harrison is headed in by Bamford.
Five added minutes.
Sub for Leeds as Rodrigo is off and Alioski is on.
Osborn one-two with Basham in the area but he drills the cross into the arms of Meslier.
Blades 0 - 1 Leeds
A late Bamford header settles this one.