United's seven game unbeaten run in the Premier League came to an end on Thursday night, as Newcastle claimed the spoils with a goal in each half at Bramall Lane.
Allan Saint-Maximin headed the opener in the first-half, before VAR went against the Blades in assisting Jonjo Shelvey's goal after the break, despite United dominating possession and creating a number of chances.
For the clash against the Magpies, boss Wilder made two changes at the top of the pitch. McBurnie and Sharp started, with Mousset and McGoldrick named amongst the substitutes.
United were characteristically quickly out of the blocks and Dubravka was called into action on five minutes, after Stevens powered an effort at goal, which looked to be looping in with the aid of a deflection, until the Newcastle stopper intervened. The Blades threatened again moments later, but from Norwood's inswinging corner to the near post, McBurnie couldn't make a clean contact despite getting in front of his marker.
The Blades continued to force the issue with McBurnie going close, but on 16 minutes it was the visitors who took the lead against the run of play. Manquillo found space to cross from the right wing and SAINT-MAXIMIN rose highest above Basham to head home. United's response was almost instant, but again Dubravka produced a big save, pushing away McBurnie's header from Basham delivery, following an switch of play by Norwood.
As the half hour mark approached, the Blades continued to create chances, but despite getting the wrong side of Dummett, Sharp couldn't get his shot on target with Dubravka advancing out of his goal. The skipper then earnt a free-kick wide on the left, but Dubravka was equal to Egan's header from Fleck's centre.
It was the home side, who were dominating the ball, who continued to push for an equaliser, but a deflection took the ball of the header of Sharp, who was ready to apply the finishing touch, from O'Connell's cross. The last action of the half saw Norwood sting the palms of Dubravka with a free-kick right on the edge of the box, after Almiron had fouled Fleck.
In the opening moments of the second period, Sharp was cautioned for a foul on Manquillo, although the Newcastle man made a full recovery, despite requiring lengthy treatment. There was one man standing between the Blades and a goal and it was Dubravka, who again was called into action to deny McBurnie with a header from Baldock's inviting cross.
The Kop were getting right behind the Blades and Sharp's last contribution before being replaced by Mousset was to have a header saved by Dubravka from point-blank range, but the assistant referee adjudged the skipper was offside from Lundstram's ball in.
On 70 minutes, the game swung decisive in the visitors favour with VAR once again going against the Blades. The assistant referee flagged for offside as Carroll flicked on into the path of SHELVEY who slotted past Henderson, referee Attwell waved play on and following a short check the decision was overturned and the goal was given.
With the clock ticking against them, the Blades looked for a way back into the game, but it wasn't to be on a frustrating night at S2, as the seven-game unbeaten run in the top-flight came to a disappointing end.
Blades: Henderson, Baldock, Stevens, Fleck, O'Connell, Basham (L. Freeman 75), Lundstram, McBurnie, Sharp (Mousset 62), Egan, Norwood.
Unused: Robinson, Jagielka, Moore, Bešić.
Newcastle: Dubravka, Manquillo, Fernandez, Clark, Dummett, Willems, Shelvey, Hayden, Almiron (Krafth 88), Saint-Maximin (Atsu 81), Carroll (Joelinton 72).
Unused: Darlow, Schar, Gayle, Longstaff.
As it happened...
Quiet start to the game. Newcastle send a testing ball forward but Basham heads clear. 0-0.
Good hold up play by Sharp. Lays the ball to Lundstram whose fierce drive is blocked.
Moments later a deflected Stevens effort is tipped over and Newcastle clear the following corner.
Low ball into the area by Fleck is turned behind.
The following corner from Norwood just evades McBurnie and Dubravka parries clear. 0-0.
Saint-Maximin makes a break down the right and dances away from his man, but his low cross is straight into the arms of Henderson. 0-0.
At the other end McBurnie drives towards the edge of the area but his shot is curled wide of the far post.
Goal for Newcastle.
Manquillo's cross is headed down and into the bottom corner by Saint-Maximin. 0-1.
What a save!
Wonderful cross by Basham straight on to the head of McBurnie who plants his header goalwards, but Dubravka dives to his left to make a brilliant stop. 0-1.
Some neat interplay by United comes to nothing as Norwood's through ball is off target as he attempts to find Stevens down the left side of the area. 0-1.
Stevens runs inside and slips the ball into the channel for Sharp who connects with his toe on the stretch but puts a difficult chance wide. 0-1.
Fleck free-kick is headed towards goal by Egan but straight at the 'keeper. 0-1.
Half a chance for the Blades when a corner loops awkardly off a head under the crossbar but O'Connell can't force it home. 0-1.
Terrific build up play by the Blades, with McBurnie at the heart of it, ends with O'Connell's drilled centre which evades everyone when only a touch was needed. 0-1.
Two added minutes
Fleck tripped on the edge of the area.
Norwood fires the free-kick around the wall but it is saved. 0-1.
Blades 0 - 1 Newcastle
Allan Saint-Maximin's header separates the teams despite United enjoying lots of the ball.
Second half is underway...
Sharp first into the book for a trip.
Great cross from the right by Baldock which is well met by McBurnie but Dubravka tips over.
From the corner, the ball is returned into the mix, but O'Connell cannot make a telling connection when on the floor. 0-1.
The game is constantly being stopped for injuries which is breaking up the Blades 'momentum.
Dubravka the latest to have treatment.
Wonderful cross by Lundstram to find Sharp who sees his header saved from six yards, whilst the flag is also raised for offside. 0-1.
Sharp is withdrawn and replaced by Lys Mousset.
Mousset combines with Basham who gets some luck as he charges into the box, but as he tries to square it, Newcastle get the block in and escape the following corner. 0-1.
Goal for Newcastle.
Carroll flicks on for Shelvey who runs clear to score despite a flag being raised for offside. VAR checks and the goal is given. 0-2.
David McGoldrick replaces Norwood.
Joelinton has replaced Carroll for Newcastle
Basham replaced by Luke Freeman.
Freeman with a deep cross from the left, McGoldrick stretching though can only smash it over the bar. 0-2.
Atsu has replaced Saint-Maximin.
Cross-field run from Baldock sees him find Mousset, the Frenchman shoots from 20 yards, it takes a deflection and goes wide. Newcastle clear the corner. 0-2.
Freeman booked for stopping a Newcastle counter.
Krafth replaces Almiron for Newcastle
Six minutes added time
Blades 0 - 2 Newcastle
Goals either side of the interval from Saint-Maximin and Shelvey earn Newcastle the points.