Chris Wilder says United will have to be at their best on Wednesday evening, when they travel to Ewood Park.
Tony Mowbray's side haven't lost in the league on home soil in over a year and the Blades boss expects Rovers to do well back in the second tier, particularly at home.
He remarked: "The Championship is a tight division, like we spoke about after the Birmingham City game.
"Can Blackburn turn those draws into wins, that's a scenario we're all trying to achieve, they've got an experienced manager and a fantastic home record.
"That started that last season in League One, after they were surprisingly relegated the season we came up."
Wilder added: "I remember there were some big clubs who could have dropped that season including Nottingham Forest and Birmingham, but unfortunately for Blackburn it was them after it went to the wire.
"They regrouped, got themselves moving in the right direction and kept the core of an experienced squad of players, they didn't have a fire sale, turned bids down, then they've since spent a bit of money, a sizeable reported fee on a young centre-forward.
"They are an ambitious club who want to do well back in the Championship and there is no reason why they won't."