Chris Wilder admits Chris Basham will be a 'big miss' for the New Year's Day encounter at Wigan but is confident the Blades will cope without the versatile performer.
Basham will serve a one-game suspension at the DW Stadium, having been sent off for two bookable offences against Blackburn Rovers at the weekend.
His manager remains of the opinion he was harshly treated, but insists the Blades must get on with things.
Wilder commented: "Bash will be a big miss in all departments, he's been outstanding since I came here, his attitude and enthusiasm is infectious and he's just such a good guy.
"He's been really good for us in a number of positions, he's consistent and he's puts himself out there.
"We recognise he was unfortunate at the weekend with the bookings he picked up, particularly the first one.
"He has to miss out, but we've got two or three options and a few different ways of coping with his absence."
Meanwhile, the Blades boss has heaped praise on fellow defender Jack O'Connell, after he made his 100th consecutive start against Rovers.
The United chief added: "Jack is an extremely dedicated young footballer, he's the first in and last out.
"He wants to do well for himself and the football club and his performances have been outstanding.
"Jack was instrumental in our success in League One and has taken to the Championship exceptionally well.
"I'm not surprised he's a coveted player and it epitomises what's he's about the play 100 games on the spin."