United begin life back in the Championship by welcoming Brentford to Bramall Lane on the opening day of the 2017/18 campaign.
The Blades will host the Bees on Saturday 5th August, before away fixtures at Middlesbrough and Cardiff City.
The first Steel City derby of the season will take place at Hillsborough in September, with the return at the Lane in January.
There are two homes games to enjoy over the festive period, with Sunderland the opponents on Boxing Day and Bolton Wanderers the final opposition of 2017 four days later.
The penultimate home game of the season sees Preston North End as the visitors, before a trip to Ashton Gate to face Bristol City brings the curtain down on the campaign on Sunday 6th May.
Click here for the full fixture list. All fixtures are subject to change.