John Fleck says the players are ready for Saturday's first away game of the new season, against the bookies favourites for the Championship.
Looking ahead Fleck remarked: "It will be a good game against Middlesbrough and they're understandably favourites to win the division.
"But there aren't any easy games in this division, Cardiff will be another tough one on Tuesday, but we're ready for these challenges and we'll see where it takes us."
And the Scottish midfielder says United can go to The Riverside in confident mood after last week's opening day victory.
He added: "It was nice to start with a win in a very tough game against Brentford. They had more of the ball but we ground it out and deserved the points.
"Teams have a lot of quality on the ball in the division, but once we're up to full speed I'm sure we'll adapt quite well.
"There will be times when we might have to change depending on the opposition and results, but we're a very settled group."