Nigel Adkins expects Millwall to be a 'tough' challenge, as the Blades go in search of a fifth consecutive home victory in all competitions at the weekend.
Speaking ahead of the 12.15pm kick-off, Adkins remarked: "We have done our homework diligently and we know Millwall are a strong unit who give little away.
"They play with two solid banks of four, but are more than capable of scoring goals as they break quickly.
"It will be a tough game, they will be difficult to breakdown and we might have to be patient.
"We could have to grind them down a bit and suck them out to create space in offensive positions.
"But we go into the game full of confidence having scored 14 goals in four recent home wins and the clean sheet on Tuesday was also very welcome."
The Gaffer concluded by urging all supporters to embrace the Club's 'Turn the Lane Pink' initiative, which will see the Lane turned into a sea of pink on Saturday as United aim to raise awareness and funds for Breast Cancer Care.
Adkins added: "Saturday is a special day, not just on the field, but off it too.
"I urge everyone to get down to the game and back the lads, but just as important come in something pink and support what is a great cause and one that the Club are firmly behind.
"Everyone behind the scenes at Bramall Lane has worked tremendously hard to make the day a success for Breast Cancer Care and hopefully everyone can dig deep and donate to what is a wonderful and much needed charity."