Nigel Clough has revealed James Wallace trained with the rest of the first-team squad on Monday and could be set to make his comeback in an U21 fixture next week.
The 23-year-old, signed in the summer from Tranmere Rovers, hasn't started a game since mid November and has been troubled with muscular problems for much of the season.
But the Blades boss is optimistic the influential midfielder could still have a part to play in United's Sky Bet League One campaign.
Clough said: "James joined the group for training on Monday morning which is obviously good news for us and him.
"We'll manage him carefully this week as we have done throughout his rehabilitation, but hopefully should everything go to plan he will get some minutes under his belt for the U21s in a game next week and we'll take it from there.
"We are still hoping to be able to call upon his services at some point before the end of the season, after initially fearing some weeks ago that wouldn't be the case."
Meanwhile, Terry Kennedy and Stefan Scougall have been pencilled in for 45 minutes each in a behind closed doors friendly on Wednesday, as the pair edge closer to competitive returns following knee injuries.
Clough added: "We hope to get Tel and Stefan a run out in midweek, they are progressing nicely and will be hopefully in contention after the Crewe game.
"We are getting a few bodies back at a crucial time of the season and that can only improve the options we have at our disposal."