Nigel Clough says three points against Fleetwood Town are imperative as the Blades look to make up ground on the teams above them in the table.
With Preston away to the MK Dons on Saturday, Clough is urging his players to make the most of the opportunity to claw back some points on at least one of their promotion rivals.
"Saturday is potentially a big weekend for us with Preston playing the MK Dons, but we have to be focused on what we have to do and that is beating Fleetwood.
"If we do that then it will be a positive day for us regardless of the other result, but a draw there coupled with a win for us would be excellent.
"We had a setback in midweek against Peterborough, but let's not forget we were minutes away from a hard fought 1-0 win and barring defensive errors we would have at least taken a point, so we have to react positively in front of our own supporters.
"We need to be bright, play at a good tempo from the off and look to score an early goal, when we do that it helps everyone inside the stadium relax."
But the Gaffer insists United can't afford to take anything for granted against the Cod Army, who he describes as having a 'close-knit' squad.
He added: "Similar to Chesterfield and Rochdale, Fleetwood have acclimatised well to life in League One and have done so by having a settled, close-knit squad, which they have gradually added to as the season as progressed.
"They had a very good side that won promotion from League Two and sometimes that consistency and continuity that success brings can be underestimated, but we know they will be looking forward to coming to Bramall Lane and expressing themselves, what we can't do is let them get a grip of the game."