Nigel Clough has acknowledged three points against Colchester United would be the ideal midweek tonic following defeat at Gillingham on Saturday, but says it won't be easy against Tony Humes's side.
The U's arrive in South Yorkshire unbeaten in four matches away from the Weston Homes Community Stadium, a run that includes a victory over Peterborough United at London Road and the Blades boss insists nothing can be taken for granted.
He remarked: "Colchester themselves have done better on the road than at home this season and that is surprising.
"So we need to be careful, because although we want to throw caution to the wind and go for the game, we don't want to fall behind at home.
"They are a solid side; they are strong defensively and will look to hit us on the break."
Meanwhile, Clough says he hopes the Bramall Lane faithful give the former striker, who is expected to lead the U's attack on Tuesday night gets the applause he deserves.
The Gaffer added: "We know their centre-forward very well and we hope Chris (Porter) gets a good reception from the supporters.
"Chris scored some important goals for us in the second-half of last season and his contribution to our success mustn't be forgotten."