Neill Collins says the Blades enter Tuesday's FA Cup fourth round replay with Fulham with a point to prove after Saturday's defeat at Crewe Alexandra.
The experienced defender, though, believes United's third clash against top-flight opposition in this season's FA Cup will represent the Blades' toughest challenge to date, emphasised by the fact that Fulham are desperate for a win themselves.
Collins commented: "As players, following Saturday, we are just glad we have an immediate opportunity to put right things that went wrong at Gresty Road.
"For whatever reason we just never got going and conceding two goals just before half-time killed the game as a contest. We huffed and puffed in the second-half and we should have had a penalty, but overall we didn't deserve anything from the game.
"Now we go to Fulham in the FA Cup and perhaps after our last two performances in the competition there is an expectation that we will go to Craven Cottage and get another good result, but this will be even more difficult than our last two matches.
"Fulham will know what we are about, they will know our threats and target areas to hurt us, but most of all they are smarting themselves and, like us, need a win for confidence.
"Obviously both teams will be focused on staying up in their respective divisions, but on Tuesday, as professionals, both teams will want to get through to the last 16 of the FA Cup.
"I just hope we can give our loyal and tremendous supporters something to cheer, but we all know just how important Saturday's game against Shrewsbury Town is and straight after the final whistle, win or lose, that is what we will be thinking about."