Nigel Clough says the Blades will be doing everything possible to beat Rotherham United on Tuesday night, but admitted Sunday's FA Cup semi-final with Hull City will take priority.
Speaking ahead of welcoming their South Yorkshire rivals to Bramall Lane, Clough remarked: "Playing Rotherham at home on a Tuesday night, five days before an FA Cup semi-final at Wembley isn't ideal preparation, but we will field our strongest side without taking any chances.
"We won't risk anybody, but obviously some of the lads that will play on Sunday are going to have to play because we haven't got a big enough squad to play a separate XI.
"We want the side to be competitive and we want a positive result, but Sunday is the obvious priority.
"The fans will be focused on Wembley, but like the players and management, we don't want to enter the weekend on the back of a defeat to our local rivals."
On the Blades hopes of a snatching the last play-off spot, the Gaffer concluded "I think we need to win five and draw one to have a chance of the top-six, we can't afford to lose on Tuesday night and we will be doing everything we can to win the game, but it will be tough.
"This game is an opportunity for certain players to put a marker down, but a lot of planning has already been doing for Hull on Sunday and the team for that game has been in my mind for a while, but you never know what might happen with injuries and illness."