Ahead of Wednesday's FA Youth Cup second round clash against Worcester City at Bramall Lane, United's U18s slipped to defeat against QPR at Shirecliffe on Saturday.
The Blades started the game really well and it was somewhat against the run of play when QPR went ahead in the 12th minute with their first attack.
United reacted well and continued to move the ball at a good tempo, although Cheeseman couldn't hit the target with two headers from consecutive Reed corners. Moments later Heh hit the crossbar after a slick move down the right.
Again, against the run of play, QPR doubled their lead in the 28th minute following another defensive slip. The R's broke down the right and it was adjudged that a combination of Reed and Ptak had committed a foul in the penalty area. Eastwood saved the resulting spot-kick but the visitors reacted quickest to fire home the rebound.
The second-half followed a similar pattern to the first. Wright and Coustrain couldn't apply the finishing touch to Fixter's cross in the 51st minute, before Whiteman and Eyre were introduced from the bench.
After Coustrain had come close to reducing the arrears, QPR broke quickly to make it 3-0. The visitors stole possession in midfield and countered swiftly before scoring at the back post.
United responded immediately and got on the scoresheet through SLEW. Eyre came close to a second after excellent work by Whiteman.
QPR rounded off the scoring in the 76th minute after some neat interchange play opened up the Blades defence and left Eastwood helpless. The last action came when Whiteman saw a superb volley excellently saved.
Coach Travis Binnion commented: "The scoreline flattered QPR a little but because we played some excellent passing football, but were naïve at times.
"The lads that played did themselves no harm, but the team selection certainly had the FA Youth Cup tie against Worcester City in mind.
"QPR are a very strong and well organised outfit who will go very close to winning the southern league this season, so we have to remain upbeat about our performance.
"Louis Reed was excellent and head and shoulders above anyone else on the pitch, whilst Joe Cheeseman is starting to put in some solid performances at the back."
Blades: Eastwood, Ptak, Kedman (Scarisbrick 67), Reed, Cheeseman, Waters, Fixter (Eyre 59), Heh, Wright (Whiteman 63), Coustrain, Slew.
Unused: Owen, Banton.