Kevin McDonald is confident the Blades can make it a Good Friday for Unitedites at Prenton Park.
The Wirral is the destination for Danny Wilson and co as the Easter action kicks off and McDonald says the players are keen to start the nine match run-in with a positive result, warning his team-mates not to underestimate Ronnie Moore's side.
Looking ahead to the challenge Rovers will pose, the Scotsman said: "Tranmere are a strong team, especially at home and I expect them to be more offensive than they were at Bramall Lane in December.
"At the time they were top of the league and they certainly came to us not to lose before thinking about winning, but they will be a total different proposition on their own pitch.
"I saw the Stevenage game on the television and the playing surface looked far from ideal, so we will have to roll our sleeves up and battle to earn the right to play football. Hopefully if we match their determination and desire then our technical ability can come into play.
"Looking at their squad, it is clear they have used the loan market to their advantage, but they also have some very good players of their own, too.
"We are certainly expecting a real tough contest, but if we are at our best there is no reason why we can't come back with all three points."