United's U21s slipped to a second consecutive home defeat in strong blustery conditions at Shirecliffe.
Monday afternoon's defeat was confirmed with a goal with just ten minutes remaining - Matty Crooks finding the target for Huddersfield.
United's team included four trialists - Chelsea's Conor Clifford and Craig Lynch, of Sunderland, both made their second appearance for Chris Morgan's side. Joining the Premiership duo were Sheffield-born Ted Cribley, who has played US college football, and Angelos Charisteas, who has played 88 times for the Greek national team, including in their 2004 European Championship success. The 32-year-old free agent played 72 minutes at Shirecliffe.
The strong wind dominated the encounter. Huddersfield, kicking down the slope and with the elements, dominated the first half. Atkinson was prominent, he shot over, had another effort saved by Willis and then side-footed against the outside of a post, whilst Gobern's header struck the top of the crossbar.
United's only two efforts of the first half saw Charisteas have a shot comfortably saved by former Blades goalkeeper, Bennett, who also deflected away a Whitehouse effort with his legs.
In the second half the Blades were the stronger force. Whitehouse fired over and Charisteas was again denied by Bennett, the goalkeeper his time tipping a shot around a post.
A Whitehouse free-kick was touched away by Bennett and Cribley fired wide after good work by McFadzean before Huddersfield netted with their only meaningful attack of the half, with 80 minutes gone. Clifford blocked an effort but the Blades failed to clear allowing Gobern to lay off for CROOKS to slot into the corner of the net.
United's only attempt to draw level before the final whistle fell to Lynch but his shot was well over the crossbar.
Blades: Willis, Hodder, McFadzean, Clifford, Kennedy, Barry, Cribley, Whitehouse, Charisteas (De Girolamo 72), Lynch, Tonne.
Unused: Pemberton, Owen, Khan, Smith.